Part of the Heart World Conference 2026 (HWC 2026), this session examines innovative strategies for cardiovascular prevention focused on combining genomics, biomarkers, digital health tools, and lifestyle approaches. The session will focus on how individualized risk profiling, based on genetic and behavioral information, can allow for effective, tailored prevention. The session emphasizes a transition from one-size-fits-all treatment to personalized prevention for better and equitable heart health outcomes.